Luis C López Selected Research

Mitochondrial encephalopathy

4/2019	Rapamycin administration is not a valid therapeutic strategy for every case of mitochondrial disease.
1/2019	β-RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9R239X mice.
1/2016	Gene Therapy Corrects Mitochondrial Dysfunction in Hematopoietic Progenitor Cells and Fibroblasts from Coq9R239X Mice.
7/2014	Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency.

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Luis C López Research Topics

Disease

20	Mitochondrial Diseases (Mitochondrial Disease) 11/2020 - 01/2006
13	Sepsis (Septicemia) 11/2017 - 07/2005
7	Coenzyme Q10 Deficiency 04/2019 - 05/2009
6	Inflammation (Inflammations) 08/2017 - 04/2007
4	Mitochondrial encephalopathy 04/2019 - 07/2014
3	Body Weight (Weight, Body) 10/2019 - 07/2014
3	Gliosis 01/2019 - 03/2013
3	Brain Diseases (Brain Disorder) 01/2016 - 02/2009
3	Cerebellar Ataxia (Dysmetria) 07/2014 - 08/2012
2	Sarcopenia 10/2019 - 11/2018
2	Squamous Cell Carcinoma of Head and Neck 01/2019 - 04/2018
2	Parkinson Disease (Parkinson's Disease) 01/2017 - 10/2009
2	Muscular Diseases (Myopathy) 07/2014 - 08/2012
2	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 07/2011 - 04/2010
2	Endotoxemia 04/2007 - 11/2006
1	Frailty 10/2019
1	Metabolic Diseases (Metabolic Disease) 09/2019
1	Brain Injuries (Brain Injury) 04/2019
1	Head and Neck Neoplasms (Head and Neck Cancer) 04/2018
1	Neuroinflammatory Diseases 01/2017
1	Stomatitis 01/2015
1	Ulcer 01/2015
1	Neoplasms (Cancer) 01/2015
1	Mucositis 01/2015
1	Neurodegenerative Diseases (Neurodegenerative Disease) 07/2014
1	Nephrotic Syndrome (Syndrome, Nephrotic) 07/2014
1	Cognitive Dysfunction 06/2012
1	Muscular Dystrophies (Muscular Dystrophy) 07/2011
1	Neuromuscular Diseases (Neuromuscular Disease) 01/2011
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 05/2009
1	Seizures (Absence Seizure) 05/2009
1	Lactic Acidosis 05/2009
1	Colonic Neoplasms (Colon Cancer) 09/2007
1	Hypoxia (Hypoxemia) 07/2005

Drug/Important Bio-Agent (IBA)

24	MelatoninIBA 10/2019 - 01/2006
5	coenzyme Q10 (CoQ10)IBA 11/2020 - 08/2012
5	Adenosine Triphosphate (ATP)IBA 01/2018 - 10/2006
5	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2017 - 11/2006
4	InflammasomesIBA 10/2019 - 01/2015
4	UbiquinoneIBA 01/2019 - 05/2009
4	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2017 - 10/2009
4	Protein Isoforms (Isoforms)IBA 01/2017 - 01/2006
4	ubiquinone 9IBA 01/2016 - 05/2009
4	Proteins (Proteins, Gene)FDA Link 01/2016 - 03/2013
4	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2014 - 01/2006
3	EnzymesIBA 11/2020 - 01/2006
3	DNA (Deoxyribonucleic Acid)IBA 01/2016 - 02/2009
3	AntioxidantsIBA 01/2014 - 01/2011
3	Mitochondrial DNA (mtDNA)IBA 06/2012 - 02/2009
2	Therapeutic UsesIBA 11/2020 - 04/2019
2	Sulfides (Thioethers)IBA 11/2020 - 01/2017
2	Glutathione (Reduced Glutathione)IBA 11/2020 - 01/2014
2	Lactic Acid (Lactate)FDA LinkGeneric 10/2019 - 11/2018
2	Sirolimus (Rapamycin)FDA Link 04/2019 - 04/2018
2	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2018 - 01/2015
2	ubiquinone 7IBA 01/2018 - 03/2013
2	NucleotidesIBA 01/2015 - 02/2009
2	NitritesIBA 01/2014 - 02/2006
2	Free RadicalsIBA 05/2011 - 04/2007
2	Nitric Oxide Synthase (NO Synthase)IBA 04/2007 - 01/2006
1	CarbonIBA 11/2020
1	sulfide quinone reductaseIBA 11/2020
1	Pharmaceutical PreparationsIBA 04/2019
1	AcidsIBA 01/2019
1	Cisplatin (Platino)FDA LinkGeneric 01/2019
1	4-hydroxybenzoic acid (p-hydroxybenzoate)IBA 01/2019
1	Salicylic Acid (2 Hydroxybenzoic Acid)FDA LinkGeneric 01/2019
1	TOR Serine-Threonine KinasesIBA 04/2018
1	SynucleinsIBA 08/2016
1	Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)IBA 03/2016
1	Messenger RNA (mRNA)IBA 01/2016
1	RetinoidsIBA 09/2015
1	NLR ProteinsIBA 09/2015
1	Transcription Factors (Transcription Factor)IBA 09/2015
1	Glutamic Acid (Glutamate)FDA Link 01/2015
1	Succinic Acid (Succinate)IBA 01/2015
1	malic acid (malate)IBA 01/2015
1	RotenoneIBA 01/2015
1	Leucine (L-Leucine)FDA Link 01/2015
1	ubiquinol-10IBA 07/2014
1	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 01/2014
1	Electron Transport Complex I (NADH-CoQ Reductase)IBA 03/2013
1	Adenosine Diphosphate (ADP)IBA 03/2013
1	Atorvastatin (Lipitor)FDA Link 10/2011
1	CytokinesIBA 04/2010
1	DystrophinIBA 04/2010
1	Nonsense Codon (Nonsense Mutation)IBA 05/2009
1	NucleosidesIBA 02/2009
1	Bovine Serum AlbuminIBA 09/2007
1	Adenosine Triphosphatases (ATPase)IBA 10/2006
1	Oxygen (Dioxygen)IBA 07/2005

Therapy/Procedure

6	Therapeutics 04/2019 - 07/2014
4	Ligation 01/2015 - 02/2006
4	Punctures 01/2015 - 02/2006
2	Radiotherapy 01/2019 - 01/2015
1	Palliative Care (Palliative Therapy) 04/2019
1	Drug Therapy (Chemotherapy) 01/2015
1	Aftercare (After-Treatment) 10/2006